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    10535434 Apparatus, systems, and methods for rapid cancer detection  
    Presented herein are systems, methods, and apparatus that analyze molecular imprints for detecting cancerous cells. Embodiments of the present disclosure include systems, methods, and apparatus...
    10534001 Methods for detecting ovarian cancer  
    The present description is related to the field of ovarian cancer diagnostics. It introduces novel biomarkers that can be used to detect presence of ovarian cancer and to provide a prognosis of...
    10534000 Methods for treatment of metastatic thyroid cancer using a PDGFR-α inhibitor  
    Provided herein are methods for identifying a subject with an increased likelihood of developing or having metastatic papillary thyroid cancer (PTC), or a subject with an increased likelihood of...
    10533227 Compositions, kits, and methods for identification, assessment, prevention and therapy of breast and ovarian cancer  
    The invention relates to newly discovered nucleic acid molecules and proteins associated with breast or ovarian cancer. Compositions, kits, and methods for detecting, characterizing, preventing,...
    10533056 Macropinocytosing human anti-CD46 antibodies and targeted cancer therapeutics  
    In various embodiments human anti-CD46 antibodies that are internalizing and enter tumor cells via the macropinocytosis pathway are provided, as well as antibody-drug conjugates (ADCs) developed...
    10533050 Methods and compositions for liver cancer therapy  
    The present disclosure provides methods of treating liver cancer and preventing liver cancer recurrence with anti-progastrin antibodies, methods of monitoring treatment efficacy of anti-progastrin...
    10533041 Peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers  
    The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The...
    10533040 Colon and pancreas cancer peptidomimetics  
    The invention relates to a peptidomimetic of an NPC-1 epitope on the MUC5AC protein which is differentially expressed in pancreatic and colorectal cancer, and diagnostic and therapeutic usages....
    10532091 Peptides and combination of peptides for use in immunotherapy against prostate cancer and other cancers  
    The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The...
    10532074 RAR selective agonists in combination with immune modulators for cancer immunotherapy  
    Disclosed herein are methods for treating cancer comprising administering CAR-modified immune cells and at least one Retinoic Acid Receptor agonist.
    10532073 RAR selective agonists in combination with immune modulators for cancer immunotherapy  
    Disclosed herein are methods for treating cancer comprising administering CAR-modified immune cells and at least one Retinoic Acid Receptor agonist.
    10532052 Combination of a 6-oxo-1,6-dihydro-pyridazine derivative having anti-cancer activity with an EGFR inhibitor  
    A pharmaceutical composition of 3-(1-{3-[5-(1-Methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]- benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile or a pharmaceutically acceptable salt and/or...
    10532040 Methods of treating cancer with herbacetin  
    The invention provides methods, uses and compounds for treating cancers. For example, certain embodiments provide a method for treating cancer in a mammal comprising administering to the mammal an...
    10531824 Diagnostic system for the detection of skin cancer  
    Methods and compositions are provided for the analysis of skin surfaces to determine the presence of neoplastic tissue. In the methods of the invention, a composition comprising a florescent probe...
    10529453 Tool that analyzes image data and generates and displays a confidence indicator along with a cancer score  
    A novel cancer scoring tool not only generates a score, but it also generates a confidence number. The tool receives a digital image of tissue of a patient. The tool identifies cell objects in the...
    10527627 Urinary polyamines as prostate cancer detection biomarkers  
    The present disclosure relates to urinary polyamines useful as prostate cancer biomarkers. In particular, the present disclosure provides a novel, highly-sensitive and specific, method for...
    10527624 Circulating tumor cell diagnostics for prostate cancer biomarkers  
    The present invention describes a method for detecting castration-resistant prostate cancer (CRPC) in a patient afflicted with prostate cancer comprising (a) performing a direct analysis...
    10526662 FALZ for use as a target for therapies to treat cancer  
    The disclosure provides methods for predicting and/or determining whether a subject has cancer based on the level of expression of BPTF. The disclosure also provides methods for determining...
    10526659 Biomarkers for colorectal cancer  
    Biomarkers and methods related to microbiota for predicting the risk of a disease, particularly colorectal cancer (CRC), are described.
    10526642 DNA methylation in colorectal and breast cancer diagnostic methods  
    The present invention relates generally to nucleic acid molecules in respect of which changes to DNA methylation levels are indicative of the onset or predisposition to the onset of a neoplasm....
    10526606 Targeting WSB1 and pVHL to treat cancer  
    Materials and methods for treating cancer (e.g., by reducing metastasis) are provided herein. For example, materials and methods for treating cancer by targeting WSB1 and/or pVHL are provided.
    10526412 Anti APRIL (a proliferation-inducing ligand) antibodies and their uses for the prognosis and/or diagnosis of cancer  
    An antibody or a fragment thereof directed against an epitope including or being constituted by at least six contiguous amino acids in the SEQ ID NO: 1 or a conformational epitope comprising or...
    10526389 Peptides and combinations of peptides for use in immunotherapy against lung cancer, including NSCLC and other cancers  
    The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The...
    10526388 Peptide derived from GPC3, pharmaceutical composition for treatment or prevention of cancer using the same, immunity inducer, and method for producing antigen-presenting cells  
    The present invention provides a peptide containing 8 or more consecutive amino acid residues in an amino acid sequence of any of SEQ ID NOS: 1 to 11 and consisting of 11 or less amino acid residues.
    10526291 Potent dual BRD4-kinase inhibitors as cancer therapeutics  
    Disclosed herein are compounds that are inhibitors of BRD4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BRD4 are also disclosed. In certain aspects,...
    10526290 Bendamustine derivatives and related compounds, and medical use thereof in cancer therapy  
    The present invention relates to bendamustine derivatives and related compounds of formula (VII), (VIII) and (IX), and medical uses thereof in particular in cancer therapy.
    10525139 Folate-conjugated molecules for delivery of toxic small molecule inhibitors to cancer cells and methods of use  
    The invention relates to novel derivatives of thapsigargin that are chemically modified with a group that targets a cell surface-expressed receptor, and pharmaceutical preparations thereof. The...
    10525118 Recombinant Mycobacterium as an immunotherapeutic agent for the treatment of cancer  
    The invention relates to a recombinant Mycobacterium cell for use as an immunotherapeutic agent in the treatment of cancer, particularly in the treatment of solid tumors. More particularly, the...
    10525104 Predictive and prognostic biomarkers related to anti-angiogenic therapy of metastatic colorectal cancer  
    The present invention provides methods for treating metastatic cancer comprising identifying subjects who will respond favorably to anti-VEGF therapy. According to certain aspects of the...
    10525091 Use of parvovirus for eliminating cancer stem cells (CSCs)  
    Described is the use of a parvovirus, preferably H-1PV, for the therapeutical elimination of cancer stem cells (CSCs), preferably neuroblastoma stem cells and glioblastoma stem cells.
    10525079 Pharmaceutical composition for preventing or treating breast cancer including crystalline polymorph of tetraarsenic hexoxide, and method for producing same  
    The present invention relates to a pharmaceutical composition for preventing or treating breast cancer which includes tetraarsenic hexoxide in which a crystalline polymorph a(As4O6-a), of...
    10525074 Combination therapy for treating cancer  
    The present invention relates to compositions comprising inhibitors of human histone methyltransferase DOT1L and one or more therapeutic agents, particularly anticancer agents, and methods of...
    10525063 Methods of reducing mammographic breast density and/or breast cancer risk  
    The present disclosure is directed to generally methods and/or compositions for treating mammographic breast density and/or breast stiffness in a patient in need thereof, such as a pre-menopausal,...
    10525037 Compounds for treatment of cancer  
    The present invention relates to pharmaceutical compositions for treating cancer comprising BRAF inhibitors, (e.g. vemurafenib) and/or MEK inhibitor, (e.g. trametinib, RO5068760), in combination...
    10525031 Lipid furan, pyrrole, and thiophene compounds for treatment of cancer, neurological disorders, and fibrotic disorders  
    Compounds, methods, and compositions are provided for the treatment of cancer, neurological disorders, and fibrotic disorders. Specifically, the invention includes administering an effective...
    10525022 Pharmaceutical composition for treating cancer, containing lactate metal salt  
    The present invention relates to: a pharmaceutical composition for treating cancer containing, as an active ingredient, a metal lactate salt, which can be dissociated, in cancer cells, into...
    10525021 Mitochondrial uncouplers for treatment of metabolic diseases and cancer  
    2-hydroxy-benzoic anilide compounds and derivatives, compositions thereof, and methods for treating metabolic diseases and cancer through uncoupling mitochondria.
    10521557 Systems and methods for providing dynamic, individualized digital therapeutics for cancer prevention, detection, treatment, and survivorship  
    Methods, systems, and apparatus, including computer programs stored on a computer-readable storage medium, for providing dynamic, individualized digital therapeutics for cancer patients and cancer...
    10519513 Cancer Biomarkers  
    Biomarkers and methods using the biomarkers for the prediction of the recurrence risk of cancer in a patient are provided.
    10519512 STK32C gene relevant to breast cancer and use thereof  
    The present invention relates to the serine threonine kinase 32C (STK32C) gene relevant to breast cancer and a use thereof, and particularly, to a composition for the diagnosis, prevention, or...
    10519506 Identification of metastasis-specific miRNA and hypomethylation signatures in human colorectal cancer  
    The present invention includes methods and biomarkers for diagnosing or detecting colorectal cancer metastasis in a human subject by comparing the Alu repeat methylation level in the biological...
    10519505 Genomic signatures of metastasis in prostate cancer  
    A method of determining the risk of metastasis of prostate cancer in a human subject who has or had prostate cancer is disclosed herein. The method is based on detecting in a prostate sample from...
    10519245 Antibodies which bind insulin-like growth factor receptor-1 (IGF1R) and methods of use thereof to treat cancer  
    There is disclosed compositions and methods relating to or derived from anti-IGF1R antibodies. More specifically, there is disclosed fully human antibodies that bind IGF1R, IGF1R-binding fragments...
    10519214 Methods and compositions for chimeric antigen receptor targeting cancer cells  
    The present invention provides a chimeric antigen receptor (CAR) that recognizes B7-H3 (CD276), as well as methods of use in the treatment of diseases and disorders.
    10519210 Multi-level specific targeting of cancer cells  
    A compound comprising, in combination: a cell surface binding ligand or internalizing factor, such as an IL-13Rα2 binding ligand; at least one effector molecule (e.g., one, two, three or more...
    10519197 Peptide-based proteasome inhibitors for treating conditions mediated by senescent cells and for treating cancer  
    The proteasome inhibitors of this invention include peptide-based compounds with a short linear sequence of amino acids. An oxo or thio group is attached to the N-terminal amino acid. A...
    10519167 3-oxa-8-azabicyclo[3.2.1]octane derivatives and their use in the treatment of cancer and hemoglobinopathies  
    A compound of formula Ia, Ib, Ic or Id: wherein: n is 1 or 2; RN is H or Me; R1 is optionally one or more halo or methyl groups; R2a and R2b are independently selected from the group consisting...
    10519152 Compounds and their use in treating cancer  
    The specification generally relates to compounds of Formula (I): and pharmaceutically acceptable salts and prodrugs thereof, where R1, R4, R5, R6, R7, Linker, X, Y, A, G, D and E have any of the...
    10519113 Kinase inhibitor compounds, compositions, and methods of treating cancer  
    The present invention relates to a compound having the structure of formula (I) or a stereoisomer, pharmaceutically acceptable salt, oxide, or solvate thereof, where X, Y, Z, R, R1, R2, R3, R4,...
    10518109 Transformable charged particle beam path cancer therapy apparatus and method of use thereof  
    The invention comprises a method and apparatus for determining a radiation beam treatment path to a tumor, comprising the steps of: (1) delivering charged particles from an accelerator, along a...

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